Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST)
Authors' conclusion
In this cohort, greater peripheral and central sensitivity were associated with reduced levels of objectively-assessed daily step counts.
Study context
- Population
- Participants of the Multicenter Osteoarthritis Study (knee osteoarthritis (OA) cohort); 55.9% female, age 62.8 ± 10.0 yearsanalysed
- Participants
- 1,873 participants
- Exposure
- Pain sensitivity and conditioned pain modulation (CPM) vs accelerometer-based physical activity
- Outcome
- Accelerometer-based physical activity: steps/day, activity intensity and sedentary time (lower back-worn monitor over 7 days)
Methodological detailsobservational cohort, multicentre, linear regression
- Observational cohort
- Multicentre
- Linear regression
Main finding
As reported in the abstract
- Greater peripheral and central sensitivity associated with lower step counts
- CPM not significantly related to any physical activity measure
- None of the exposures significantly related to sedentary time
Observational data: associations, not effects.
Original publication
Associations of pain sensitivity and conditioned pain modulation with physical activity: findings from the Multicenter Osteoarthritis Study (MOST). Osteoarthritis Cartilage. Published 18 May 2024. doi:10.
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