Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort
Main finding · Quadriceps intra-MAT deposition, 4-year rate of changeResult — go to the resultEstimate 71.5 mm²/4 years 95% CI 27.9–115.1Authors' conclusion
EHOA is associated with longitudinal worsening of thigh muscle composition only in participants without concomitant KOA.
Study context
- Population
- Hand osteoarthritis (OA) participants of the Osteoarthritis Initiative cohort (67.1±7.5 years, female/male:2.9)
- Participants
- 844 thighs
- Exposure
- Erosive hand OA vs hand OA with no erosion
- Erosive hand OA (EHOA)n = 211
- non-EHOAn = 633reference
- Outcome
- Difference between EHOA and non-EHOA in 4-year rate of change of intramuscular adipose tissue (intra-MAT) deposition and contractile (non-fat) area of thigh muscles (MRI, deep-learning algorithm)
- Follow-up
- 4 years
Methodological detailspropensity score-matched, longitudinal, multilevel mixed-effect regression
- Propensity score-matched
- Longitudinal
- Multilevel mixed-effect regression
Main finding
As reported in the abstract
Quadriceps intra-MAT deposition, 4-year rate of change
Estimate
71.5 mm²/4 years
95% CI 27.9–115.1
Observational data: associations, not effects.
Further findings
| Outcome | Estimate (%/4 years) (95% CI) |
|---|---|
| Quadriceps contractile area, 4-year rate of change | −1.8 (−2.6 to −1.0) |
Thigh muscle quality, stratified by radiographic knee OA (KOA) (subgroup)
- EHOA associated with adverse changes in thigh muscle quality only in participants without KOA
Original publication
Erosive hand osteoarthritis and sarcopenia: data from Osteoarthritis Initiative cohort. Ann Rheum Dis. Published 15 May 2024. doi:10.
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