Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort
Authors' conclusion
LBP and ZRP were associated with EHOA with clinical and radiographic severity in HOA.
Study context
- Population
- Patients with hand OA in the DIGICOD cohort
- Participants
- 410 patients
- Exposure
- Erosive hand OA vs hand OA without erosions
- Erosive hand osteoarthritis (EHOA)n = 140
- Without EHOAn = 270reference
- Outcome
- Serum intestinal permeability biomarkers (LBP, FABP2, sCD14, ZRP), calprotectin and high-sensitivity C-Reactive Protein (hs-CRP) in EHOA vs without EHOA
Methodological detailsDIGICOD cohort, logistic regression adjusted for age, BMI and sex
- DIGICOD cohort
- Logistic regression adjusted for age, BMI and sex
Main finding
As reported in the abstract
Serum intestinal permeability biomarkers
- EHOA vs Without EHOA: P = 0.001
- EHOA vs Without EHOA: P = 0.04
- Mann-Whitney U test; adjusted for age, BMI and sex
Observational data: associations, not effects.
Further findings
Correlations with HOA clinical and radiographic severity (Spearman)
- Zonulin-related proteins (ZRP) vs Verbruggen score
- r=0.14 p=0.005
- ZRP vs Kellgren-Lawrence sum score of both hands
- r=0.12 p=0.023
- Lipopolysaccharide binding protein (LBP) vs number of erosive joints
- r=0.14 p=0.0006
- Hs-CRP vs AUSCAN pain
- r=0.14 p=0.008
- LBP vs AUSCAN pain
- r=0.10 p=0.042
Original publication
Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort. Osteoarthritis Cartilage. Published 12 March 2025. doi:10.
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