Associations of trabecular bone texture with anatomical phases of osteoarthritis evolution and its progression in finger joints: Results from the Nor-Hand study
Authors' conclusion
TB texture roughness decreases with OA phases and lower baseline roughness is associated with an increased risk of developing EOA.
Study context
- Population
- Persons with hand osteoarthritis (OA) in the Norwegian Hand OA (Nor-Hand) study; DIP and PIP joints on hand radiographs
- Participants
- 300 persons
- Exposure
- Trabecular bone (TB) texture (fractal dimensions) across Verbruggen-Veys anatomical phases of hand OA; baseline TB texture and progression to erosive OA
- Outcome
- Differences in TB texture (fractal dimensions FDH, FDV, FDSta) with anatomical phases of hand OA, and association of baseline TB texture with progression to EOA
- Follow-up
- 3.5 years
Methodological detailslinear mixed models, Poisson models, 3.5 years follow-up
- Linear mixed models
- Poisson models
- 3.5 years follow-up
Main finding
As reported in the abstract
Distal FDH, difference in means vs normal phase
Each group vs normalDifference (95% CI)
Stationary
−0.008(−0.013 to −0.003)
JSN
−0.031(−0.041 to −0.021)
Erosive
−0.067(−0.080 to −0.055)
Remodeled
−0.059(−0.070 to −0.046)
Observational data: associations, not effects.
Further findings
| Outcome | Risk ratio (95% CI) | |
|---|---|---|
| Progression to EOA at follow-up per higher baseline proximal FDs · 3.5 yearsFDV | 0.71 (0.60–0.83) | |
| Progression to EOA at follow-up per higher baseline proximal FDs · 3.5 yearsFDH | 0.80 (0.70–0.92) | |
| Progression to EOA at follow-up per higher baseline proximal FDs · 3.5 yearsFDSta | 0.71 (0.59–0.84) | |
| 0.512Risk ratio (log scale) |
Progression to erosive OA (EOA) at follow-up per higher baseline proximal fractal dimensions (FDs) · 3.5 years
- Higher baseline proximal FDs associated with reduced risk of progression to EOA
- No evident relationships for baseline distal FDs
Original publication
Associations of trabecular bone texture with anatomical phases of osteoarthritis evolution and its progression in finger joints: Results from the Nor-Hand study. Osteoarthritis Cartilage. Published 11 July 2026. doi:10.
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