Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis: The Hand OSTeoArthritis in Secondary care cohort
Authors' conclusion
BMLs are rare yet associated with CLLs that are more common, both cross-sectionally and longitudinally, both adding to the OA process.
Study context
- Population
- Patients with hand osteoarthritis (OA), Hand OSTeoArthritis in Secondary care cohort (mean age 61 years, 84% women); PIP and DIP joints, right-hand MRI
- Participants
- 261 patients
- Exposure
- Bone Marrow Lesions (BMLs) vs no BMLs; Collateral Ligament Lesions (CLLs) vs no CLLs
- Outcome
- Longitudinal association of BMLs with CLL development (and of CLLs with BML development) at the same joint side
- Follow-up
- Year two and year four
Methodological detailslongitudinal, MRI-based, joint-side level analysis adjusted for patient effect
- Longitudinal
- MRI-based
- Joint-side level analysis adjusted for patient effect
Main finding
As reported in the abstract
CLL development at the same joint side in baseline joint sides without CLLs · year two and four
BMLs vs No BMLsOdds ratio (95% CI)
Year two; adjusted for patient effect
3.7(1.5–9.1)
Year four; adjusted for patient effect
4.9(2.3–10.7)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| BML development at the same joint side in baseline joint sides without BMLs · year two and fourCLLsvs No CLLsYear two | 9.2 (3.9–22.1) | |
| BML development at the same joint side in baseline joint sides without BMLs · year two and fourCLLsvs No CLLsYear four | 11.0 (5.8–20.9) | |
| 0.050.21520Odds ratio (log scale) |
Prevalence of BMLs (joint sides) · baseline and year four
- Baseline
- 113/4169 (3%)
- Year four
- 89/3356 (3%)
Prevalence of any CLL (joint sides) · baseline and year four
- Baseline
- 500/4169 (12%)
- Year four
- 559/3356 (17%)
Cross-sectional association of BMLs and CLL
- The presence of BMLs and CLL was cross-sectionally associated
Original publication
Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis: The Hand OSTeoArthritis in Secondary care cohort. Osteoarthritis Cartilage. Published 24 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →