Tibial hemodynamics during walking in knee osteoarthritis with bone marrow lesions: A cross-sectional study
Authors' conclusion
Pathological hypoxia of the medial aspect of the tibial tuberosity during walking appears specific to patients with KOA-BMLs. This dynamic impairment correlates with BML volume.
Study context
- Population
- Young adults, older adults and patients with knee osteoarthritis (KOA) with or without bone marrow lesions (BMLs), March-July 202574 analysed
- Participants
- 18 / 18 / 18 / 20
- Exposure
- KOA with BMLs vs young adults, older adults and KOA without BMLs
- Youngn = 18reference
- Older adultsn = 18reference
- KOAn = 18reference
- KOA-BMLn = 20
- Outcome
- Change in TOI of the medial tibial tuberosity measured by near-infrared spectroscopy (NIRS) during a 3-min walking phase and a 5-min post-walking phase
Methodological detailslinear mixed models
- Linear mixed models
Main finding
As reported in the abstract
Decrease in TOI
MD (95% CI)
KOA-BMLvs Young
−14.43(−17.30 to −11.56)
KOA-BMLvs Older adults
−11.94(−14.67 to −9.21)
KOA-BMLvs KOA
−9.99(−12.73 to −7.25)
Observational data: associations, not effects.
Further findings
Correlation of tissue oxygenation index (TOI) during walking with BML volume (KOA-BML)
- Lower TOI during walking correlated with larger BML volume
- r −0.634 (95% CI −0.840, −0.266)
Original publication
Tibial hemodynamics during walking in knee osteoarthritis with bone marrow lesions: A cross-sectional study. Osteoarthritis Cartilage. Published 20 April 2026. doi:10.
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