T1Gd is reduced in bone marrow lesions overlying cartilage in the hip
Authors' conclusion
T1Gd is reduced in overlying cartilage in hips from a population-based sample of adults aged 20-49, which suggests BMLs are associated with local cartilage degeneration in hips.
Study context
- Population
- Population-based study of hip pain in 20–49-year-oldsrecruited
- Participants
- 128 participants
- Exposure
- Hip cartilage overlying Bone Marrow Lesions (BMLs) vs matched regions in age- and sex-matched controls
- BMLn = 32
- Controln = 32reference
- Outcome
- Mean T1Gd of cartilage overlying BMLs
Methodological detailsage- and sex-matched controls, linear mixed-effects models, delayed Gadolinium Enhanced MR Imaging of Cartilage (dGEMRIC) MRI
- Age- and sex-matched controls
- Linear mixed-effects models
- dGEMRIC MRI
Main finding
As reported in the abstract
Mean T1Gd of overlying cartilage
BML vs ControlDifference, ms (95% CI)
Acetabular BMLs
−105(−175 to −35)
Femoral BMLs
−8(−141 to 124)
Observational data: associations, not effects.
Further findings
| Outcome | Difference (95% CI) | |
|---|---|---|
| Mean T1Gd in overlying cartilage, cysticvs non-cystic BMLCI too large to provide certainty in this difference | −3 (−126 to 121) | |
| −200−1000100200Difference (linear scale) |
Original publication
T1Gd is reduced in bone marrow lesions overlying cartilage in the hip. Osteoarthritis Cartilage. Published 28 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →