Latent transition analysis of pain phenotypes in people at risk of knee osteoarthritis: The Multicenter Osteoarthritis Study (MOST) cohort study
Authors' conclusion
Distinct PPs were identified in those at risk of KOA that remained stable over time, suggesting these trait-like features may require consideration for comprehensive management of the symptom experience.
Study context
- Population
- People without radiographic knee OA (Kellgren-Lawrence grade 0, knee pain ≤30/100 at T1), MOST; 5-, 7- and 12-year visits59% females
- Participants
- 348 people
- Exposure
- Class 1 vs Class 2 vs Class 3
- Outcome
- Pain phenotypes and their transitions over time
- Follow-up
- T1 (5 years), T2 (7 years), T3 (12 years)
Methodological detailslatent transition analysis, Bayesian Information Criteria, secondary analysis of the MOST cohort
- Latent transition analysis
- Bayesian Information Criteria
- Secondary analysis of the MOST cohort
Main finding
As reported in the abstract
T1–T3
Participants remaining in the same class
86%
Participants who transitioned over time
14%
Observational data: associations, not effects.
Original publication
Latent transition analysis of pain phenotypes in people at risk of knee osteoarthritis: The MOST cohort study. Osteoarthritis Cartilage. Published 6 March 2025. doi:10.
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