Exploring different models of pain phenotypes and their association with pain worsening in people with early knee osteoarthritis: The MOST cohort study
Authors' conclusion
Phenotypes based upon various factors thought to be important for the pain experience were identified in those with EKOA but were not significantly related to pain worsening.
Study context
- Population
- People with early-stage knee OA (pain intensity ≤3/10, Kellgren and Lawrence grade ≤2, intermittent pain none to sometimes, no constant pain) from the Multicenter Osteoarthritis Study
- Participants
- 750 vs 333
- Exposure
- Model A vs Model B
- Model An = 750
- Model Bn = 333
- Outcome
- Association between pain phenotypes and pain worsening
- Follow-up
- Two years
Methodological detailslatent class analysis, logistic regression, multicentre
- Latent class analysis
- Logistic regression
- Multicentre
Main finding
As reported in the abstract
Association of pain phenotypes with pain worsening
- Model A: 3-class solution; most severe phenotype dominated by psychosocial factors, widespread pain (WSP) and nervous system sensitization
- Model B: 4-class solution; Model A phenotype plus gait variables, quadriceps strength and comorbidities dominant
- None of the phenotypes in either model had a significant relationship with pain worsening
Observational data: associations, not effects.
Original publication
Exploring different models of pain phenotypes and their association with pain worsening in people with early knee osteoarthritis: The MOST cohort study. Osteoarthritis Cartilage. Published 13 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →