Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain
Authors' conclusion
The five hand OA phenotypes were associated with pain at baseline and 3.5 years later. The phenotype with the least OA severity, but higher burden of biopsychosocial factors reported more pain than the phenotype with the most severe OA, reflecting the symptom-structure discordance of the hand OA pain experience.
Study context
- Population
- Participants with hand osteoarthritis (OA) from the Nor-Hand study baseline examination (2016–17), follow-up 2019–21five classes
- Exposure
- Biopsychosocial hand OA phenotypes vs the overall healthiest class
- Outcome
- Hand and overall bodily pain intensity (NRS, 0-10)
- Follow-up
- Baseline and (2019-21)
Methodological detailslatent class analysis, linear regression
- Latent class analysis
- Linear regression
Main finding
As reported in the abstract
Hand pain (NRS 0-10) · baseline
Beta
3.65
95% CI 2.53–4.75
Least severe OA, higher biopsychosocial burden
Beta
1.03
95% CI 0.41–1.65
Most severe hand OA, low biopsychosocial burden
Observational data: associations, not effects.
Further findings
Overall bodily pain and pain at follow-up · follow-up (2019-21)
- Results were similar for overall bodily pain and at follow-up
Change in pain over time
- Changes in pain were small, but the association between a separate class defined by higher levels of biopsychosocial burden and pain changes was significant
Original publication
Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain. Osteoarthritis Cartilage. Published 30 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →