Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort
Main finding · Incident radiographic eHOA per SD of serum IL-7Result — go to the resultRelative risk per SD 1.30 95% CI 1.09–1.55Authors' conclusion
This exploratory study suggests an association of elevated interleukin-7, an inflammatory cytokine, with incident eHOA, while other cytokines or biomarkers of metabolic inflammation were not associated.
Study context
- Population
- Osteoarthritis Initiative participants with hand radiographs at baseline and 48 months and baseline biospecimens
- Participants
- 86 vs 1,282
- Exposure
- Incident radiographic erosive hand osteoarthritis (OA) cases vs random representative sample
- Incident erosive hand osteoarthritis (eHOA)n = 86
- Random representative samplen = 1,282reference
- Outcome
- Incident radiographic erosive hand OA
- Follow-up
- 48 months
Methodological detailslongitudinal, random representative subcohort, biomarker measurement blinded to case status, adjusted for age, gender, race, smoking and BMI, adjusted for multiple analyses
- Longitudinal
- Random representative subcohort
- Biomarker measurement blinded to case status
- Adjusted for age, gender, race, smoking and BMI
- Adjusted for multiple analyses
Main finding
Incident radiographic eHOA per SD of serum IL-7
Relative risk per SD
1.30
95% CI 1.09–1.55
p trend 0.01
Incident eHOA
RR per SD 1.30 (95% CI 1.09–1.55); p trend 0.01
Per SD of serum IL-7, as printed
As reported in the abstract
Observational data: associations, not effects.
Original publication
Associations of inflammatory and metabolic biomarkers with incident erosive hand osteoarthritis in the osteoarthritis initiative cohort. Osteoarthritis Cartilage. Published 3 February 2024. doi:10.
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