Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model
Authors' conclusion
RNA-sequencing results show that metabolic activation and recuperation of growth plate morphology are induced by T3 in OA chondrocytes, indicating terminal maturation is accelerated.
Study context
- Population
- Explant cartilage from OA patientsRT-qPCR validation set n = 22
- Participants
- 8 participants
- Comparison
- T3 vs no T3, ex vivo
- Outcome
- Differential gene expression with T3
Methodological detailsex vivo osteochondral explant model, RNA-sequencing, RT-qPCR validation in independent sample set
- Ex vivo osteochondral explant model
- RNA-sequencing
- RT-qPCR validation in independent sample set
Main finding
As reported in the abstract
Differentially expressed genes, main pathways linked to extracellular matrix and ossification
247
OA risk genes significantly affected in cartilage by T3 (incl. COL12A1, TNC, SPARC, PAPPA)
37
Original publication
Thyroid hormone induces ossification and terminal maturation in a preserved OA cartilage biomimetic model. Arthritis Res Ther. Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →