Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis
Authors' conclusion
Around age 70 years nearly all persons with knee OA have arterial calcifications, which progress substantially.
Study context
- Population
- Persons satisfying the clinical ACR classification criteria for knee OA36 male
- Participants
- 118 persons
- Exposure
- Males vs Females
- Malesn = 36
- Outcome
- Prevalence and progression of arterial calcifications on whole-body CT
- Follow-up
- 2 years
Methodological detailswhole-body CT at baseline and after 2 years, multivariable linear and logistic regression
- Whole-body CT at baseline and after 2 years
- Multivariable linear and logistic regression
Main finding
As reported in the abstract
Prevalence of arterial calcification · baseline
Prevalence range across arterial beds
41.8% and 94.4%
Observational data: associations, not effects.
Further findings
Median
| Outcome | Males | Females |
|---|---|---|
| Annual progression rate of arterial calcifications · 2 years | 13.1% | 15.7% |
Association of OA severity with calcification
- 5 points lower (worse) WOMAC associated with 1% faster progression of arterial calcifications
- P = 0.008
- Baseline femoropopliteal calcifications associated with higher Kellgren-Lawrence grade (more severe knee OA)
- Structural OA severity not associated with progression
Original publication
Prevalence and progression of arterial calcifications on computed tomography in humans with knee osteoarthritis. Rheumatology (Oxford). Published 22 April 2024. doi:10.
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