Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study
Authors' conclusion
Serum levels of a combination of hydroxylated metabolites of arachidonic acid may have prognostic utility for knee pain
Study context
- Population
- Participants in the Knee Pain in the Community (KPIC) cohort studyKPIC cohort
- Participants
- 154 participants
- Outcome
- Associations of serum oxylipins with knee pain (NRS item 3, average pain)/radiographic osteoarthritis (OA) (KL) at baseline and with knee pain at follow-up
- Follow-up
- 3 years
Methodological detailsobservational, linear regression, ROC analysis
- Observational
- Linear regression
- ROC analysis
Main finding
As reported in the abstract
Longitudinal association of baseline serum oxylipins with follow-up knee pain (NRS item 3, average pain) · 3 year follow-up
Baseline serum 5-HETE, β
1.724 (0.677-2.77) (95% CI)
Observational data: associations, not effects.
Further findings
Cross-sectional association with current self-reported knee pain (numerical rating scale (NRS) item 3, average pain) · baseline
- Serum 14,15-DHET, β
- 0.827 (0.34-1.31) (95% CI)
- Serum 12-HETE, β
- 4.090 (1.92-6.26) (95% CI)
- Serum anandamide, β
- 3.060 (1.35-4.77) (95% CI)
Cross-sectional association with Kellgren and Lawrence (KL) scores · baseline
- Serum 9-HETE, β
- 0.467 (0.18-0.75) (95% CI)
- Serum 15-HETE, β
- 0.759 (0.29-1.22) (95% CI)
- Serum 14-hydroxydocosahexaenoic acid, β
- 0.483 (0.24-0.73) (95% CI)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Serum levels of hydroxylated metabolites of arachidonic acid cross-sectionally and longitudinally predict knee pain progression: an observational cohort study. Osteoarthritis Cartilage. Published 20 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →