Dysbiosis of gut microbiota, a potential mediator of bile acid compositions, and prevalence of hand synovitis: a community-based study
Authors' conclusion
Our findings suggest that gut microbiota dysbiosis is associated with the prevalence of hand synovitis. Such an association appears to be partially mediated by plasma bile acids.
Study context
- Population
- Community-based observational study participants (mean age 63.2 years; women 58.8%)
- Participants
- 1,336 participants
- Exposure
- Gut microbiota dysbiosis and hand synovitis prevalence; mediation by plasma bile acids
- Outcome
- Prevalent hand synovitis (US-assessed)
Methodological detailscommunity-based, observational
- Community-based
- Observational
Main finding
As reported in the abstract
Prevalent hand synovitis
Prevalent hand synovitis
18.3%
Unilateral hand synovitis
13.6%
Bilateral hand synovitis
4.7%
Observational data: associations, not effects.
Further findings
Laterality and number of joints affected by hand synovitis
- Similar associations observed
Mediation of Prevotella–hand synovitis association by bile acids
- Mediation proportion, tauroursodeoxycholic acid
- 25.7%
- Mediation proportion, glycoursodeoxycholic acid
- 21.6%
- Partially mediated
Original publication
Dysbiosis of gut microbiota, a potential mediator of bile acid compositions, and prevalence of hand synovitis: a community-based study. Rheumatology (Oxford). Published 24 January 2023. doi:10.
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