Oral microbiome dysbiosis and oral-gut microbial network disruption in hand osteoarthritis: data from the Xiangya Osteoarthritis Study
Main finding · Oral microbiome richness, composition and taxa abundanceResult — go to the resultβ 0.437 95% CI 0.174–0.699Authors' conclusion
Oral microbiome dysbiosis and disruption of the oral-gut microbiome network are associated with prevalent SHOA.
Study context
- Population
- Participants of the Xiangya Osteoarthritis (XO) Study, an ongoing community-based observational study
- Participants
- 712 vs 52
- Exposure
- Symptomatic hand OA vs controls without symptomatic hand osteoarthritis (SHOA)
- Controlsn = 712reference
- SHOAn = 52
- Outcome
- Oral microbiome richness, composition and taxa abundance
Methodological detailscommunity-based observational study, 16S ribosomal RNA gene sequencing of saliva
- Community-based observational study
- 16S ribosomal RNA gene sequencing of saliva
Main finding
As reported in the abstract
β
0.437
95% CI 0.174–0.699
P = 0.001
- Significantly lower oral microbial richness in SHOA
- P = 0.007
- Altered oral microbial composition in SHOA
- P = 0.007
Observational data: associations, not effects.
Further findings
- Oral Trichococcus abundance vs gut KEGG pathway of tyrosine metabolism, r
- 0.137
- Number of significant correlations within the oral-gut microbiome network markedly reduced in SHOA vs controls
- p=0.001, Q=0.047
Original publication
Oral microbiome dysbiosis and oral-gut microbial network disruption in hand osteoarthritis: data from the Xiangya Osteoarthritis Study. RMD Open. Published 21 July 2026. doi:10.
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