Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study
Authors' conclusion
Alterations of gut fungal microbiota and the fungi-bacteria correlation network are associated with knee synovitis.
Study context
- Population
- Community-based participants (mean age 63.2 years; women 58.8%) with US of both knees and faecal gut fungal and bacterial microbiota sequencing
- Participants
- 977 participants
- Exposure
- Knee synovitis vs no synovitis
- Knee synovitisn = 191
- Outcome
- Associations of gut fungal microbiota (α-diversity, β-diversity, relative abundance of taxa) and fungi-bacteria correlation network with knee synovitis
Methodological detailscommunity-based
- Community-based
Main finding
As reported in the abstract
| Group | Value | Network nodes | Network edges | Average number of neighbours |
|---|---|---|---|---|
| Knee synovitis | 19.5% | 93 | 107 | 2.3 |
| Without synovitis | 153 | 244 | 3.2 |
Value
Knee synovitis19.5%
Without synovitis— not stated in the abstract
Network nodes
Knee synovitis93
Without synovitis153
Network edges
Knee synovitis107
Without synovitis244
Average number of neighbours
Knee synovitis2.3
Without synovitis3.2
Observational data: associations, not effects.
Original publication
Gut-joint axis in knee synovitis: gut fungal dysbiosis and altered fungi–bacteria correlation network identified in a community-based study. RMD Open. Published 18 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →