Association of Bone Shape and Alignment Analyzed Using Statistical Shape Modeling With Severity of First Metatarsophalangeal Joint Osteoarthritis
Authors' conclusion
Variations in the shape and alignment of the medial cuneiform, first metatarsal, and proximal and distal phalanx of the hallux are significantly associated with radiographic severity of first MTP joint OA.
Study context
- Population
- Individuals with clinically diagnosed symptomatic first MTP joint OA (aged 22 to 85 years); weightbearing lateral and dorsoplantar radiographs105 females
- Participants
- 185 individuals
- Exposure
- Bone shape mode scores by radiographic severity category
- None/mildn = 35
- Moderaten = 69
- Severen = 81
- Outcome
- Association between radiographic severity and bone shape mode scores (adjusted ORs, ordinal regression)
Methodological detailsstatistical shape modeling, ordinal regression adjusted for confounders
- Statistical shape modeling
- Ordinal regression adjusted for confounders
Main finding
As reported in the abstract
Bone shape modes associated with radiographic severity
- Lateral view: 16 modes included (83.2% of total shape variance); modes associated with severity
- 4
- Dorsoplantar view: 15 modes included (82.6% of total shape variance); modes associated with severity
- 6
Observational data: associations, not effects.
Original publication
Association of Bone Shape and Alignment Analyzed Using Statistical Shape Modeling With Severity of First Metatarsophalangeal Joint Osteoarthritis. Arthritis Care Res (Hoboken). Published 17 December 2023. doi:10.
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