The different subtypes of cam morphology as defined by statistical shape modeling and their relationship with the development of hip osteoarthritis: A nationwide prospective cohort study (CHECK) with 10 years follow-up
Authors' conclusion
We identified four distinct morphological subtypes of cam morphology defined by alpha angle. Only some subtypes were found acting as risk factors for RHOA at 10-year follow-up, which differed between males and females.
Study context
- Population
- Participants aged 45–65 years in the nationwide CHECK cohort; hips free of OA at baseline (Kellgren & Lawrence (KL) grade <2)
- Participants
- 1,002 participants
- Exposure
- Statistical shape modeling (SSM)-based subtypes of cam morphology and incident radiographic hip OA
- Outcome
- Incident radiographic hip OA (KL grade≥2, or a total hip replacement)
- Follow-up
- 10-year follow-up
Methodological detailsnationwide, 10-year follow-up, statistical shape modeling, logistic regression, stratified by sex
- Nationwide
- 10-year follow-up
- Statistical shape modeling
- Logistic regression
- Stratified by sex
Main finding
As reported in the abstract
Incident RHOA by cam morphology subtype
Sex-combined: mode 3 (flattened head-neck junction) associated with incident radiographic hip osteoarthritis (RHOA), OR
1.14, 1.02-1.27
Females: modes 3 and 4 associated with RHOA; female mode 4 (slightly flattened neck with subtle curvature) protective, OR
0.88, 0.80-0.98
Observational data: associations, not effects.
Further findings
Association of SSM modes with baseline cam morphology (alpha angle ≥60°)
- Cam subtypes captured in modes 1, 3, 4 and 5 (sex-combined, males and females); Odds ratios (ORs) ranging from
- 0.39 (0.27-0.58) to 2.25 (1.64-3.10)
Original publication
The different subtypes of cam morphology as defined by statistical shape modeling and their relationship with the development of hip osteoarthritis: A nationwide prospective cohort study (CHECK) with 10 years follow-up. Osteoarthritis Cartilage. Published 8 August 2024. doi:10.
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