Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years
Authors' conclusion
Cam morphology poses the hip at 2-13 times increased odds for developing RHOA within a 10-year follow-up. The association was particularly strong for large cam morphology and end-stage RHOA, while the strength of association was consistent over time.
Study context
- Population
- Participants aged 45–65 years in the CHECK cohort; hips free of OA at baseline (Kellgren & Lawrence (KL) grade <2)
- Participants
- 1,002 participants
- Exposure
- Cam morphology and large cam morphology vs hips without cam morphology
- Outcome
- Development of incident RHOA (KL grade≥2) and end-stage RHOA (KL grade≥3)
- Follow-up
- 2-, 5-, 8-, and 10-year follow-ups
Methodological detailsnationwide, logistic regression with generalized estimating equation, Cox regression, adjusted for age, sex and BMI
- Nationwide
- Logistic regression with generalized estimating equation
- Cox regression
- Adjusted for age, sex and BMI
Main finding
As reported in the abstract
Incident RHOA (KL grade≥2), at all follow-ups
Cam morphology, aOR range
2.7 (95% CI 1.8-4.1) to 2.9 (95% CI 2.0-4.4)
Large cam morphology, aOR range
2.5 (95% CI 1.5-4.3) to 4.2 (95% CI 2.2-8.3)
Observational data: associations, not effects.
Further findings
End-stage radiographic hip osteoarthritis (RHOA) (KL grade≥3) · 2-, 5-, 8-, and 10-year follow-ups
- Cam morphology, aOR range
- 4.9 (95% CI 1.8-13.2) to 8.5 (95% CI 1.1-64.4)
- Large cam morphology, aOR range
- 6.7 (95% CI 3.1-14.7) to 12.7 (95% CI 1.9-84.4)
Original publication
Cam morphology is strongly and consistently associated with development of radiographic hip osteoarthritis throughout 4 follow-up visits within 10 years. Osteoarthritis Cartilage. Published 19 August 2023. doi:10.
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