Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits
Authors' conclusion
Through MR analysis, we have identified numerous plasma proteins associated with OA-related traits, shedding light on protein-mediated mechanisms and offering promising therapeutic targets for OA.
Study context
- Population
- Thousands of plasma proteins and 12 osteoarthritis (OA)-related traits
- Outcome
- Circulating proteins causally associated with OA-related traits
Methodological detailstwo-sample Mendelian randomisation (MR), Bayesian colocalisation, Steiger filtering analysis
- Two-sample MR
- Bayesian colocalisation
- Steiger filtering analysis
Main finding
As reported in the abstract
Circulating proteins with putatively causal effects on OA-related traits
- Dozens of circulating proteins identified with putatively causal effects on OA-related traits
- Majority of these proteins were drug targets or considered druggable
Original publication
Evaluating the causal effect of circulating proteome on the risk of osteoarthritis-related traits. Ann Rheum Dis. Published 18 August 2023. doi:10.
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