Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource
Authors' conclusion
Plasma CRTAC1 is a specific biomarker for OA and a predictor of OA risk and progression to joint replacement. Adding ACAN and NCAN protein levels to the CRTAC1 model improved the prediction of OA.
Study context
- Population
- UK Biobank participants with plasma proteins measured1,462 plasma proteins
- Participants
- 54,265 participants
- Exposure
- Plasma CRTAC1 level and osteoarthritis (OA)
- Outcome
- Association of plasma proteins with prevalent OA, incident OA and progression to joint replacement
Methodological detailsproteomic analysis (Olink Explore platform), validation in an independent population
- Proteomic analysis (Olink Explore platform)
- Validation in an independent population
Main finding
As reported in the abstract
Association of plasma CRTAC1 level with prevalent and incident OA and progression to joint replacement
CRTAC1Odds ratio (95% CI)
Prevalent knee OA (strongest association)
1.34(1.27–1.41)
Prevalent hip OA
1.19(1.11–1.28)
Observational data: associations, not effects.
Further findings
Knee or hip OA within 5 years, highest vs lowest quintile of risk (CRTAC1, age, sex, BMI)
- 10-fold risk in highest vs lowest quintile
Adding ACAN and NCAN to the model
- Improved prediction of OA but not joint replacement
CUB domain-containing protein 1 and prior joint replacement
- Association replicated
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank Resource. Arthritis Rheumatol. Published 28 December 2022. doi:10.
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