Plasma Cartilage Acidic Protein 1 Measured by ELISA Is Associated With the Progression to Total Joint Replacement in Postmenopausal Women
Main finding · TJR risk per 1 SD increase in plasma CRTAC1Result — go to the resultOdds ratio 1.80 95% CI 1.11–2.92Authors' conclusion
CRTAC1 is a new risk indicator of TJR for OA in postmenopausal women.
Study context
- Population
- Postmenopausal women in a prospective cohort; median follow-up 18 years38 total joint replacement (TJR) cases
- Participants
- 478 women
- Comparison
- Plasma CRTAC1 and incident TJR for osteoarthritis (OA)
- TJR casesn = 38
- Outcome
- Incident TJR for OA
- Follow-up
- Median 18 years
Methodological detailsage- and BMI-matched 1:2, conditional logistic regression
- Age- and BMI-matched 1:2
- Conditional logistic regression
Main finding
TJR risk per 1 SD increase in plasma CRTAC1
Odds ratio
1.80
95% CI 1.11–2.92
CRTAC1 per 1 SD increase
OR 1.80 (95% CI 1.11–2.92)
Per 1 SD increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
TJR risk with urinary CTX-II
| aOR (95% CI) | ||
|---|---|---|
| CTX-II | 1.83 (1.11–3.00) | |
| 0.20.5125Adjusted odds ratio (log scale) |
CRTAC1 and CTX-II in the same model
- Both markers significantly associated with TJR with similar ORs
Original publication
Plasma Cartilage Acidic Protein 1 Measured by ELISA Is Associated With the Progression to Total Joint Replacement in Postmenopausal Women. J Rheumatol. Published 1 November 2023. doi:10.
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