The epigenomic landscape of primary tissues in osteoarthritis
Authors' conclusion
We found methylation sites with a potential mechanistically causal role in osteoarthritis and associated these with likely effector genes.
Study context
- Population
- Patients who underwent total knee replacement for OA; primary chondrocytes of low-grade and high-grade cartilage, synovium, infrapatellar fat pad and blood
- Participants
- 314 patients
- Outcome
- Associations between genetic variants and methylation (mQTL), between methylation and gene expression (eQTM), colocalisation with OA GWAS signals and likely effector genes
Methodological detailsgenome-wide methylation quantitative trait locus (mQTL) and expression quantitative trait methylation (eQTM) mapping, integration with genome-wide association studies (GWAS), colocalisation
- Genome-wide mQTL and eQTM mapping
- Integration with GWAS
- Colocalisation
Main finding
As reported in the abstract
- Likely effector genes identified by tissue-specific integration of colocalisation and eQTM results
- 50
Original publication
The epigenomic landscape of primary tissues in osteoarthritis. Ann Rheum Dis. Published 26 February 2026. doi:10.
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