The role of type I collagen fragment C1M in knee osteoarthritis. A longitudinal biomarker study using data from the OA-FNIH consortium
Authors' conclusion
The inverse association of C1M with OA progression compared with the positive association of uCTXII indicates that a reduced concentration of one neoepitope (of type I collagen) and an elevated concentration of another (from type II collagen) are each associated with the risk of OA progression.
Study context
- Population
- Individuals with knee osteoarthritis (OA), OA-FNIH biomarker consortium
- Participants
- 600 individuals
- Comparison
- Progressor groups vs non-progressors
- Non-progressorsn = 200reference
- JSLn = 103
- Painn = 103
- JSL and painn = 194
- Outcome
- Association of type I (sC1M) and type II (sC2M, uCTX-II) collagen neoepitopes, at baseline and time-integrated over 12 and 24 months, with odds of OA progression case status
Methodological detailslongitudinal biomarker study, OA-FNIH biomarker consortium, logistic regression
- Longitudinal biomarker study
- OA-FNIH biomarker consortium
- Logistic regression
Main finding
As reported in the abstract
Lower sC1M levels and JSL progression
JSL vs Non-progressorsOdds ratio (CI)
sC1M 0 M
0.43(0.28–0.68)
sC1M 12 M
0.43(0.27–0.68)
sC1M 24 M
0.55(0.35–0.86)
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | |
|---|---|---|
| Higher uCTX-II levels and JSL progressionJSLvs Non-progressorsuCTX-II 0 M | 1.54 (1.01–2.37) | |
| Higher uCTX-II levels and JSL progressionJSLvs Non-progressorsuCTX-II 12 M | 1.73 (1.11–2.7) | |
| Higher uCTX-II levels and JSL progressionJSLvs Non-progressorsuCTX-II 24 M | 2.05 (1.27,3.29) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
The role of type I collagen fragment C1M in knee osteoarthritis. A longitudinal biomarker study using data from the OA-FNIH consortium. Osteoarthritis Cartilage. Published 24 February 2026. doi:10.
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