Effect of intra-knee injection of autologous adipose stem cells or mesenchymal vascular components on short-term outcomes in patients with knee osteoarthritis: an updated meta-analysis of randomized controlled trials
Authors' conclusion
In conclusion, in osteoarthritis of the knee, single or multiple intra-articular injections of autologous ASCs or ADSVF have shown significant pain improvement and safety in the short term in the absence of adjuvant therapy. Significant improvements in cartilage status were also shown.
Study context
- Population
- Patients with knee osteoarthritis (OA)7 randomized controlled trials (RCTs)
- Comparison
- Single or multiple intra-articular injections of autologous ASCs or adipose-derived stromal vascular fraction (ADSVF) vs placebo or hyaluronic acid
- Outcome
- Pain relief
- Follow-up
- Short term
Pooled result
As reported in the abstract
Z
3.10
P < 0.0001
Single injection ASCs or ADSVF
Z
4.66
P < 0.00001
Multiple injections ASCs or ADSVF
Further pooled results
| Outcome | Z | P value |
|---|---|---|
| Function, short termSingle injection ASCs or ADSVF vs Control | 2.61 | P < 0.009 |
| Function, short termMultiple injections ASCs or ADSVF vs Control | 2.80 | P = 0.005 |
Cartilage condition on MRI
- Cartilage condition on MRI, first of two analyses
- Z = 8.14; P < 0.000001
- Cartilage condition on MRI, second of two analyses
- Z = 5.58; P < 0.00001
- Significant improvement in cartilage condition vs control on MRI
- The abstract does not state which of the two analyses is single and which is multiple injection
Original publication
Effect of intra-knee injection of autologous adipose stem cells or mesenchymal vascular components on short-term outcomes in patients with knee osteoarthritis: an updated meta-analysis of randomized controlled trials. Arthritis Res Ther. Published 10 August 2023. doi:10.
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