High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis : A Randomized Controlled Multicenter Trial
Authors' conclusion
The results do not support the superiority of high-dose exercise over low-dose exercise for most outcomes. However, small benefits with high-dose exercise were found for knee function in sports and recreation and for QoL.
Study context
- Population
- Patients with diagnosed knee OA and a history of pain and decreased knee function; primary health care facilities, Sweden and Norway
- Participants
- 189 patients
- Comparison
- High-dose vs low-dose exercise therapy
- High-dosen = 98
- Low-dosen = 91reference
- Primary endpoint
- Mean difference in KOOS scores between groups
- Follow-up
- End of the intervention (3 months)
Methodological detailsmulticentre, superiority
- Multicentre
- Superiority
Primary result
As reported in the abstract
KOOS scores
- Both groups improved over time, but there were no benefits of high-dose therapy in most comparisons
Secondary outcomes
KOOS function in sports and recreation · end of treatment and 6-month follow-up
- High-dose therapy was superior
Quality of life (QoL) · 6 and 12 months
- A small benefit of high-dose therapy
Original publication
High- Versus Low-Dose Exercise Therapy for Knee Osteoarthritis : A Randomized Controlled Multicenter Trial. Ann Intern Med. Published 24 January 2023. doi:10.
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