Osteoarthritis

Relationship Between Number of Different Lower‐Limb Resistance Exercises Prescribed in a Program and Exercise Outcomes in People With Knee Osteoarthritis: A Systematic Review With Meta‐Regression

Arthritis Care Res (Hoboken)Published Systematic review with meta-regression of randomised controlled trials

Authors' conclusion

There was no relationship between the number of different lower-limb resistance exercises prescribed in a program and change in knee pain or self-reported function.

Study context

Population
People with knee OA in RCTs of land-based resistance exercise vs nonexercise interventions; CENTRAL, MEDLINE and Embase searched up to January 4, 2024
Participants
3,364 people44 trials
Comparison
Number of different lower-limb resistance exercises prescribed
Outcome
Relationship between number of different exercises prescribed and standardized mean differences (SMDs) for pain and function
Methodological detailscovariates: intervention duration, frequency per week, resistance exercise machine use, comparator type
  • Covariates: intervention duration, frequency per week, resistance exercise machine use, comparator type

Pooled result

As reported in the abstract

Relationship between number of prescribed exercises and change in pain and self-reported function (meta-regression)

Change in pain: slope coefficient, SMD units (95% CI −0.14 to 0.05); no relationship

−0.04

Self-reported function: SMD (95% CI −0.12 to 0.05); no relationship

−0.04

Number of resistance exercises, range (mean ± SD 5.0 ± 3.0)

1 to 12

Further pooled results

Sensitivity analysis after removing 31 trials with overall unclear/high risk of bias

No change in relationships

Original publication

Relationship Between Number of Different Lower‐Limb Resistance Exercises Prescribed in a Program and Exercise Outcomes in People With Knee Osteoarthritis: A Systematic Review With Meta‐Regression. Arthritis Care Res (Hoboken). Published 14 January 2025. doi:10.1002/acr.25476

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