Body composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis
Authors' conclusion
Higher FMI at baseline and the presence of low muscle mass were independently associated with worse physical function over 4 years, but not with pain. Higher TFM/LFM and SMI at baseline were associated with better mental health and vitality over time.
Study context
- Population
- Patients with symptomatic knee and/or hip osteoarthritis (OA) in the KHOALA cohort; body composition by DXA in a subsample at year 3290 knee and 114 hip OA analysed
- Exposure
- Body composition measures and changes in health-related quality of life (HRQoL)
- Outcome
- Changes in patient-reported outcomes: SF-36 (physical functioning, pain, mental health, vitality) and OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL) (physical activity, pain, mental health)
Methodological detailsmulticentre, longitudinal, GEE models
- Multicentre
- Longitudinal
- GEE models
Main finding
As reported in the abstract
Higher FMI at baseline and worse physical functioning, β (95% CI −0.03 to −0.01), p<0.0001
−0.02
Presence of low lean mass and worse physical functioning, β (95% CI −0.02 to 0.02), p=0.02
−0.21
Higher TFM/LFM at baseline and better mental health, β (95% CI 0.02 to 0.15), p=0.008
0.09
Higher SMI at baseline and better mental health, β (95% CI 0.006 to 0.02), p<0.0001
0.01
Observational data: associations, not effects.
Original publication
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