Comparison of definitions of early knee osteoarthritis for likelihood of progression at 2-year and 5-year follow-up: the Multicenter Osteoarthritis Study
Authors' conclusion
Most knees with early OA are stable and do not progress. Some painful knees experience worse pain but not structural progression and vice versa.
Study context
- Population
- Multicenter Osteoarthritis (MOST) Study participants with early knee osteoarthritis (OA) (at least minimal knee pain, WOMAC pain ≥3/20, with pre-radiographic OA); mean age 65 years, 60% female, 90% white, mean BMI 29.2 kg/m²2-year analysis
- Participants
- 750 participants
- Exposure
- Different definitions of early knee OA
- Outcome
- Worsening OA combining structural (Kellgren and Lawrence grade ≥2 with joint space narrowing ≥1) and symptom (WOMAC pain ≥6 with increase ≥2 from baseline) outcomes
- Follow-up
- 2 or 5 years
Methodological detailslongitudinal follow-up, multicentre
- Longitudinal follow-up
- Multicentre
Main finding
As reported in the abstract
Combined worsening OA outcome
Early OA knees with the combined outcome
Fewer than 10%
Observational data: associations, not effects.
Further findings
- Knees with either structural or symptom worsening, several early OA definitions
- roughly 20%
- Sample size needed for 2-year trials of either, but not both, outcomes
- over 1200 patients
Original publication
Comparison of definitions of early knee osteoarthritis for likelihood of progression at 2-year and 5-year follow-up: the Multicenter Osteoarthritis Study. Ann Rheum Dis. Published 2 January 2025. doi:10.
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