Partitioning knee osteoarthritis genetic variants based on body mass index (BMI) association to improve polygenic risk prediction
Authors' conclusion
Half of KOA-associated variants overlap with BMI loci.
Study context
- Population
- White European participants in the UK Biobank146 knee osteoarthritis (KOA) variants
- Participants
- 345,080 participants
- Comparison
- KOA-BMI PRS vs KOA-nonBMI PRS
- Outcome
- Incident knee OA
Methodological detailspolygenic risk score partitioning, UK Biobank
- Polygenic risk score partitioning
- UK Biobank
Performance
As reported in the abstract
Incident knee OA, OR per SD of PRS
| Test or model | OR per SD | 95% CI | BMI-adjusted OR | BMI-adjusted 95% CI | OR before BMI adjustment | OR after BMI adjustment |
|---|---|---|---|---|---|---|
| KOA-BMI PRS | 1.23 | 1.20-1.26 | 1.18 | 1.15-1.21 | ||
| KOA-nonBMI PRS | 1.24 | 1.23 |
OR per SD
KOA-BMI PRS1.23
KOA-nonBMI PRS— not stated in the abstract
95% CI
KOA-BMI PRS1.20-1.26
KOA-nonBMI PRS— not stated in the abstract
BMI-adjusted OR
KOA-BMI PRS1.18
KOA-nonBMI PRS— not stated in the abstract
BMI-adjusted 95% CI
KOA-BMI PRS1.15-1.21
KOA-nonBMI PRS— not stated in the abstract
OR before BMI adjustment
KOA-BMI PRS— not stated in the abstract
KOA-nonBMI PRS1.24
OR after BMI adjustment
KOA-BMI PRS— not stated in the abstract
KOA-nonBMI PRS1.23
Further findings
Variants classified as BMI-associated
- BMI-associated KOA variants, of 146
- 73
Association of KOA-nonBMI PRS with BMI
- β in KOA cases
- −0.09 (95% CI −0.17 to −0.01)
- Not associated in controls
KOA across BMI strata
- KOA-nonBMI PRS effect diminished in higher BMI strata; KOA-BMI PRS effects stable
Original publication
Partitioning knee osteoarthritis genetic variants based on BMI association to improve polygenic risk prediction. Osteoarthritis Cartilage. Published 30 September 2025. doi:10.
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