Cartilage turnover, but not novel synovial collagen marker, is associated with joint damage progression in osteoarthritis patients
Main finding · Knee and/or hip OA progressionResult — go to the resultOdds ratio 2.57 95% CI 1.57–4.18Authors' conclusion
Increased urinary CTX-II, but not Col 3-4, is independently associated with a higher risk of structural progression in patients with knee or hip OA.
Study context
- Population
- Patients with symptomatic knee or hip osteoarthritis (OA) (mean age 62 yr, 62% women), Kellgren-Lawrence (KL) score ≥2, KHOALA cohort
- Participants
- 449 patients
- Exposure
- Baseline urinary CTX-II and serum Col 3-4, fourth vs first quartile
- Outcome
- Progression: one-point increase in KL score on knee or hip radiographs and/or joint replacement
- Follow-up
- 5 years
Methodological detailsmultivariable discrete-time survival models
- Multivariable discrete-time survival models
Main finding
Knee and/or hip OA progression
Odds ratio
2.57
95% CI 1.57–4.18
CTX-II Q4vs CTX-II Q1
OR 2.57 (95% CI 1.57–4.18)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Knee OA progression onlyCTX-II Q4vs CTX-II Q1 | 2.36 (1.32–4.21) | |
| Hip OA progression onlyCTX-II Q4vs CTX-II Q1 | 3.39 (1.42–8.11) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Cartilage turnover, but not novel synovial collagen marker, is associated with joint damage progression in osteoarthritis patients. Rheumatology (Oxford). Published 26 September 2025. doi:10.
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