Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis
Authors' conclusion
Our findings suggest that IL-6-driven mPFC dysfunction is a potential pathway linking KOA-related inflammation to MCI, while highlighting the combined utility of ReHo/ALFF metrics in mPFC, precuneus, and temporal regions as potential neuroimaging biomarkers.
Study context
- Population
- Patients with knee OA with/without mild cognitive impairment, and healthy controls63 knee osteoarthritis (KOA) patients
- Comparison
- Healthy controls vs KOA-MCI vs KOA-non-MCI
- Outcome
- Inflammation-mediated brain functional alterations (resting-state fMRI ReHo/Amplitude of Low-Frequency Fluctuation (ALFF))
Methodological detailsneuroimaging, inflammatory biomarkers, machine learning, mediation analysis, external validation
- Neuroimaging
- Inflammatory biomarkers
- Machine learning
- Mediation analysis
- External validation
Main finding
As reported in the abstract
Machine learning models with medial prefrontal cortex (mPFC) Regional Homogeneity (ReHo) features classified mild cognitive impairment (MCI) status, validated in an external dataset (AUC)
0.87
Original publication
Inflammation-mediated regional brain alterations associated with mild cognitive impairment in knee osteoarthritis. Arthritis Res Ther. Published 26 September 2025. doi:10.
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