Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort
Authors' conclusion
With sufficient treatment duration, GLP-1RA therapies might be disease-modifying for KOA patients with comorbid T2DM, possibly mediated by weight loss.
Study context
- Population
- Participants with knee OA and comorbid T2DM in the Shanghai Osteoarthritis Cohort (adults >45 years with clinically diagnosed OA), enrolled 1 January 2011 to 1 January 2017
- Participants
- 233 vs 1,574
- Exposure
- GLP-1RA exposure vs no GLP-1RA exposure
- GLP-1RAn = 233
- non-GLP-1RAn = 1,574reference
- Outcome
- Incidence of knee surgery after enrolment
Methodological detailsobservational, multicentre, before-and-after comparison
- Observational
- Multicentre
- Before-and-after comparison
Main finding
As reported in the abstract
Incidence of knee surgery
Adjusted p=0.014
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Adjusted mean difference (kg) (95% CI) | P value | |
|---|---|---|---|
| Weight change from baselineMore weight loss in GLP-1RA | −7.29 (−8.07 to −6.50) | P < 0.001 | |
| −10−505Difference, kg (linear scale) |
| Outcome | Adjusted mean difference (mm) (95% CI) | P value | |
|---|---|---|---|
| Cartilage-loss velocity, medial femorotibial jointAdjusted for baseline characteristics | −0.02 (−0.03 to −0.002) | P = 0.004 | |
| −0.04−0.0200.02Difference, mm (linear scale) |
| Outcome | After treatment | Before treatment | P value |
|---|---|---|---|
| Cartilage loss velocity, medial femorotibial joint, within GLP-1RA (after vs before treatment) | −0.03 ± 0.05 mm/year | −0.05 ± 0.07 mm/year | P < 0.001 |
- Cartilage loss velocity, medial femorotibial joint, within GLP-1RA (after vs before treatment): before-and-after comparison within GLP-1RA
Symptom-relieving medication consumption, within GLP-1RA (before-and-after)
- Significant decrease of symptom-relieving medication consumption
Mediation of GLP-1RA association with decreased knee surgery
- Mediation proportion by weight reduction
- 32.1%
- Mediation by glycaemic control (too small to calculate)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Glucagon-like peptide-1 receptor agonists as a disease-modifying therapy for knee osteoarthritis mediated by weight loss: findings from the Shanghai Osteoarthritis Cohort. Ann Rheum Dis. Published 31 May 2023. doi:10.
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