Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials
Authors' conclusion
PDE and DE interventions may offer the most effective approach for weight loss, potentially leading to improvements in pain and physical function among overweight/obese individuals with KOA if they achieve more than 7% weight loss.
Study context
- Population
- Overweight/obese adults with knee osteoarthritis (OA) (knee OA (KOA))
- Participants
- 2,800 adults13 RCTs
- Comparison
- Weight-loss interventions vs control comparators
- Outcome
- Weight change (kg), MD vs control
Methodological detailsfrequentist approach, meta-regression
- Frequentist approach
- Meta-regression
Pooled result
As reported in the abstract
Each group vs controlMD, kg (95% CI)
PDEmost effective approach
−11.2(−16.0 to −6.5)
DEleast effective approach
−4.7(−6.7 to −2.7)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Pain (0-20 scale), SMD vs controlDEvs ControlOnly DE outperformed control | −2.2 (−4.1 to −0.21) | |
| Pain (0-20 scale), SMD vs controlPDEvs ControlNot superior to control | −3.9 (−8.4 to 0.5) | |
| −10−505Difference (linear scale) |
Pain relief by weight reduction (meta-regression)
- Significant pain relief may be anticipated with weight reduction of at least
- 7%
- Prediction intervals; regardless of intervention
Original publication
Comparison of weight loss interventions in overweight and obese adults with knee osteoarthritis: A systematic review and network meta-analysis of randomized trials. Osteoarthritis Cartilage. Published 2 September 2024. doi:10.
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