Gut Microbiomics of Sustained Knee Pain in Patients With Knee Osteoarthritis
Authors' conclusion
Gut microbes may play a significant role in sustained knee pain in patients with knee OA after TKR, potentially through their activation of inflammatory pathways, lipid metabolism, and central sensitization.
Study context
- Population
- Patients receiving total knee replacement (TKR) because of primary knee osteoarthritis (OA)
- Participants
- 20 patients
- Comparison
- Sustained postsurgery knee pain vs no such pain after TKR for knee OA
- Painn = 10
- Nonpainn = 10reference
- Outcome
- Association of gut microbes with postsurgery-sustained knee pain
- Follow-up
- ≥ 1 year after TKR
Methodological detailsage-, sex- and BMI-matched, 16S rRNA sequencing, plasma metabolomic profiling
- Age-, sex- and BMI-matched
- 16S rRNA sequencing
- Plasma metabolomic profiling
Main finding
As reported in the abstract
Differentially abundant bacterial taxa (linear discriminant analysis)
Taxa highly abundant in the pain group (P < 0.05 for all)
13
Taxa highly abundant in the nonpain group (P < 0.05 for all)
5
Observational data: associations, not effects.
Further findings
Plasma metabolites correlated with the 18 taxa
- Metabolites measured
- 622
- Metabolites significantly correlated with the 18 taxa (P < 0.05 for all)
- 231
- Metabolites (of 231) separating pain from nonpain patients (sparse PLS-DA)
- 30
- Total variance explained by the 30 metabolites
- 29%
- Enriched pathways: arachidonic acid metabolic pathway, bile acid biosynthesis, linoleic acid metabolism
Original publication
Gut Microbiomics of Sustained Knee Pain in Patients With Knee Osteoarthritis. J Rheumatol. Published 1 September 2024. doi:10.
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