Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis
Authors' conclusion
This study provides overall protein and gene profiles of PVNS and identifies the crucial role of TGFβ in synovial invasion pathology.
Study context
- Population
- Patients with pigmented villonodular synovitis, osteoarthritis (OA) patients and control individuals (synovial tissue)RNA-seq 6/7/19
- Comparison
- Pigmented villonodular synovitis (PVNS) synovium vs control and OA synovium
- Outcome
- Synovial protein and gene profiles; TGFβ role in invasion
Methodological detailsRNA sequencing, label-free proteomics, in vitro
- RNA sequencing
- Label-free proteomics
- In vitro
Main finding
As reported in the abstract
- Differentially expressed proteins in PVNS tissue
- 522
Original publication
Mapping and Analysis of Protein and Gene Profile Identification of the Important Role of Transforming Growth Factor Beta in Synovial Invasion in Patients With Pigmented Villonodular Synovitis. Arthritis Rheumatol. Published 29 August 2024. doi:10.
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