Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis
Authors' conclusion
Muscle health is associated with the presence and severity of KOA and differs by sex.
Study context
- Population
- Older men and women (mean ± SD age 76.1 ± 4.9 years; 57% female) in the Study of Muscle, Mobility, and Aging with standing knee radiographs and knee pain assessments57% female
- Participants
- 655 men
- Exposure
- Kellgren-Lawrence grade (KLG) 3-4 and KLG 2 vs KLG 0-1
- Outcome
- Muscle composition, power and energetics by KOA presence and severity (adjusted models)
Methodological detailssecondary analysis of the Study of Muscle, Mobility, and Aging cohort, adjusted models
- Secondary analysis of the Study of Muscle, Mobility, and Aging cohort
- Adjusted models
Main finding
As reported in the abstract
Muscle fat infiltration (MFI), mean
0.008 %
95% CI 0.004%–0.011%
greater MFI
Leg power, mean
−51.56 W
95% CI −74.03 to −29.10 W
lower leg power
Specific power, mean
−5.38 W/L
95% CI −7.31 to −3.45 W/L
lower specific power
- Overall, presence and severity of knee osteoarthritis (KOA) associated with greater MFI, lower leg power and specific power, and reduced oxidative phosphorylation
- P for trend < 0.036
Observational data: associations, not effects.
Further findings
Mitochondrial energetics by sex
- Reduced energetics only in female patients with KOA vs female patients without KOA
- P for trend < 0.007
Pain × KLG interaction
- No interactions found between pain and KLG status
Associations among those with KOA
- MFI and oxidative phosphorylation associated with thigh fat-free muscle (FFM) volume, leg power, and specific power
Original publication
Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis. Arthritis Rheumatol. Published 22 August 2024. doi:10.
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