Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging
Authors' conclusion
Our results in older adult SOMMA participants indicate that knee OA is associated with genes and pathways expressed in skeletal muscle that are involved in pain sensitization, BCAA catabolism, muscle function preservation, calcium transport and storage, inflammation, and extracellular matrix remodeling.
Study context
- Population
- Older adult participants of the Study of Muscle, Mobility and Aging (SOMMA) with knee radiographs and vastus lateralis RNA sequencing
- Participants
- 326 / 197 / 112
- Exposure
- Radiographic knee osteoarthritis (OA) vs controls
- Controlsn = 326reference
- Kellgren-Lawrence (KL) ≥ 2n = 197
- KL ≥ 3n = 112
- Outcome
- Skeletal muscle gene expression associated with radiographic knee OA (KL grades)
Methodological detailsbulk RNA sequencing in vastus lateralis muscle, differential gene expression analysis, nested case groups
- Bulk RNA sequencing in vastus lateralis muscle
- Differential gene expression analysis
- Nested case groups
Main finding
As reported in the abstract
Genes associated with KL ≥ 2
27
Genes associated with KL ≥ 3
41
Genes significantly associated in both contrasts
16
Genes (of 16) with larger association magnitude with more severe OA (KL ≥ 3)
15
Observational data: associations, not effects.
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Original publication
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