Identification of CD64 as a marker for the destructive potential of synovitis in osteoarthritis
Authors' conclusion
Together, these results indicate that synovial CD64 expression is associated with the expression of proteolytic enzymes and inflammatory markers related to structural damage in OA.
Study context
- Population
- End-stage OA patients undergoing joint replacement surgery (synovial biopsies)
- Outcome
- CD64 (FcγRI) as a marker of the damaging potential of synovitis in OA
Main finding
As reported in the abstract
- Wide range of CD64 expression in OA synovium
- FCGR1 positively correlated with S100A8, S100A9, IL1B, IL6 and MMP1/2/3/9/13 expression
- CD64 protein correlated with MMP1, MMP3, MMP9, MMP13 and S100A9
- Synovial CD64 protein in OAS-CM source tissue significantly associated with OAS-CM-induced MMP1, MMP3 and especially ADAMTS4 expression in cultured fibroblasts, but not chondrocytes
Original publication
Identification of CD64 as a marker for the destructive potential of synovitis in osteoarthritis. Rheumatology (Oxford). Published 21 June 2023. doi:10.
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