Soluble low affinity nerve growth factor receptor (sLNGFR) may regulate pain in knee osteoarthritis
Authors' conclusion
This study suggests that endogenous or cleaved sLNGFR, but not soluble TrkA may participate in OA pain modulation
Study context
- Population
- Subjects with knee osteoarthritis (OA) who underwent total knee arthroplasty; synovial fluid analysed
- Participants
- 43 subjects
- Outcome
- Correlation of soluble neurotrophin receptors (sLNGFR, soluble TrkA), NGF pathway proteins, neurotrophins and cytokines in synovial fluid with VAS pain
Main finding
As reported in the abstract
Correlations with VAS pain score · prior to surgery
Visual analogue scale (VAS) vs β-NGF, r
0.34
sLNGFR vs VAS, r
0.33
β-NGF/soluble tropomyosin receptor kinase (TrkA) ratio vs VAS, r
0.80
Pain vs β-NGF/sLNGFR ratio, r (no correlation)
−0.08
Further findings
Correlations with TNF-α
- TNF-α vs β-NGF, r
- 0.83
- TNF-α vs NT-3, r
- 0.66
- TNF-α vs brain-derived neurotrophic factor (BDNF), r
- 0.50
- TNF-α vs ProNGF, r
- −0.74
- TNF-α vs soluble TrkA, r
- 0.62
- TNF-α vs sLNGFR, r
- 0.26
Original publication
Soluble low affinity nerve growth factor receptor (sLNGFR) may regulate pain in knee osteoarthritis. Clin Exp Rheumatol. Published 19 June 2023. doi:10.
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