Discovery of calcite as a new pro-inflammatory calcium-containing crystal in human osteoarthritic synovial fluid
Authors' conclusion
This study highlights the unique role of Raman spectroscopy in OA crystal research and identified calcite as a novel pro-inflammatory crystal type in OA synovial fluid.
Study context
- Population
- Synovial fluid from knee osteoarthritis (OA) patients undergoing total joint arthroplasty
- Participants
- 32 synovial fluid samples
- Outcome
- Characterization of calcium-containing crystals in OA synovial fluid by Raman spectroscopy, and biological effects of calcite crystals
Methodological detailsRaman spectroscopy, in vitro cell stimulation
- Raman spectroscopy
- In vitro cell stimulation
Main finding
As reported in the abstract
Calcium-containing crystals in OA synovial fluid
Calcite crystals
93.8 %
Calcium pyrophosphate
37.5 %
Basic calcium phosphate
21.8 %
Dolomite
25 %
Further findings
Cellular response to calcite crystal exposure
- Increased production of innate immune-derived cytokines by PBMCs when co-stimulated with lipopolysaccharide (LPS)
- HACs and FLSs: enhanced secretion of pro-inflammatory molecules and altered expression of extracellular matrix remodeling enzymes
Original publication
Discovery of calcite as a new pro-inflammatory calcium-containing crystal in human osteoarthritic synovial fluid. Osteoarthritis Cartilage. Published 26 May 2024. doi:10.
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