Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
Authors' conclusion
Our data support that increased flSIRT1 serum levels are a potential molecular endotype for cartilage-related structural improvement post-KJD, while NT/CT SIRT1 appears to correlate with osteophyte and PIIANP/CTX-II reduction at baseline, to potentially indicate baseline OA severity.
Study context
- Population
- Patients undergoing knee joint distraction (KJD) for knee OA
- Outcome
- Serum SIRT1 levels and 2-year structural outcomes post-KJD
- Follow-up
- 2 years
Methodological detailslongitudinal cohort, two-year longitudinal study, indirect ELISA, sandwich ELISA
- Longitudinal cohort
- Two-year longitudinal study
- Indirect ELISA
- Sandwich ELISA
Main finding
As reported in the abstract
2 years
- N-terminal (NT)/C-terminal (CT) SIRT1 serum levels significantly increased with increased osteophytes and PIIANP/CTX-II at baseline
- Increase in NT/CT SIRT1 associated with less denuded bone post-KJD
- flSIRT1 showed upward trend in serum level, accompanied by reduced denuded bone (2-year adjusted values)
- 2-year-adjusted flSIRT1 showed steeper linear regression for cartilage and bone-related structural improvement than NT/CT SIRT1
Observational data: associations, not effects.
Original publication
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1. Arthritis Res Ther. Published 24 May 2024. doi:10.
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