Mesenchymal stem cells for chronic knee pain secondary to osteoarthritis: A systematic review and meta-analysis of randomized trials
Pooled result · Pain relief (10 cm VAS)Result — go to the resultWeighted mean difference −0.74 cm 95% CI −1.16 to −0.33Authors' conclusion
Intra-articular injection of MSCs for chronic knee pain associated with OA probably provides little to no improvement in pain or physical function.
Study context
- Population
- Patients with chronic pain associated with knee osteoarthritis (OA)
- Participants
- 807 patients16 trials
- Comparison
- MSC therapy vs placebo or usual care
- Outcome
- Pain relief (10 cm VAS)
- Follow-up
- 3-6 months
Methodological detailsrandom-effects meta-analysis, GRADE certainty of evidence
- Random-effects meta-analysis
- GRADE certainty of evidence
Pooled result
As reported in the abstract
Weighted mean difference
−0.74 cm
95% CI −1.16 to −0.33
MSC therapyvs Placebo or usual care
weighted mean difference −0.74 cm (95% CI −1.16 to −0.33)
Further pooled results
| Outcome | Weighted mean difference (points) (95% CI) | |
|---|---|---|
| Physical functioning (SF-36 physical functioning subscale, 100-point) · 3-6 monthsMID 10-points; moderate certainty | 2.23 (−0.97 to 5.43) | |
| Physical functioning (SF-36 PF subscale, 100-point) · 12 monthsLow certainty | 19.36 (−0.19 to 38.9) | |
| −2002040Difference, points (linear scale) |
| Outcome | Weighted mean difference (cm) (95% CI) | |
|---|---|---|
| Pain (10 cm VAS) · 12 monthsModerate certainty | −0.73 (−1.69 to 0.24) | |
| −2−101Difference, cm (linear scale) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Any adverse eventsLow certainty | 2.67 (1.19–5.99) | |
| Pain and swelling of the knee jointLow certainty | 1.58 (1.04–2.38) | |
| 0.20.5125Relative risk (log scale) |
Original publication
Mesenchymal stem cells for chronic knee pain secondary to osteoarthritis: A systematic review and meta-analysis of randomized trials. Osteoarthritis Cartilage. Published 20 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →