Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies
Authors' conclusion
Upregulation of AP-1 family genes in the synovium and increased concentrations of CXCL8, MMP9, and VEGF were detected in the synovial fluid of the hypertrophic group of HOA patients, potentially stimulating the differentiation of SMSCs towards the cartilage and thereby contributing to severe osteophyte formation.
Study context
- Population
- Patients with hip OA of variable bone morphology undergoing total hip arthroplasty
- Participants
- 30 patients
- Comparison
- Hypertrophic vs normotrophic hip OA synovium, synovial mesenchymal stem cells (SMSCs) and synovial fluid
- Outcome
- Synovial gene expression, SMSC differentiation and synovial fluid cytokines
Methodological detailsRNA sequencing, RT-qPCR, cytokine array, differentiation and colony-forming unit assays
- RNA sequencing
- RT-qPCR
- Cytokine array
- Differentiation and colony-forming unit assays
Main finding
As reported in the abstract
Differentially expressed genes, predominantly IL-17 signalling pathway
103
Hub genes in protein-protein interaction (PPI) network (incl. MYC, CXCL8, ATF3, NR4A1, ZC3H12A, NR4A2, FOSB, FOSL1)
20
Hub genes belonging to the AP-1 family
4
Original publication
Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies. Arthritis Res Ther. Published 10 January 2024. doi:10.
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