RAGE signalling contributes to oxidative stress and inflammation in knee osteoarthritis patients with metabolic syndrome
Authors' conclusion
We conclude that enhanced function of RAGE axis could be one of the mechanisms by which metabolic syndrome leads to KO.
Study context
- Population
- Patients with knee OA fulfilling ACR diagnostic criteria undergoing total knee replacement surgery
- Participants
- 80 patients
- Exposure
- Knee osteoarthritis (KO) with metabolic syndrome vs KO without metabolic syndrome
- Outcome
- RAGE axis, oxidative stress and inflammatory markers
Main finding
As reported in the abstract
- Enhanced protein expression of RAGE and its ligands AGEs and HMGB-1 in knee joint tissue in KO with MetS vs KO without MetS
- Gene expression of oxidative stress regulators (NADPH) and inflammation (NFĸB) upregulated in KO with MetS vs KO alone
- Higher levels of advanced oxidation products and IL-17 in synovial fluid of KO with MetS
- Enhanced oxidative stress and inflammatory markers also reflected in serum of KO with MetS
Observational data: associations, not effects.
Original publication
RAGE signalling contributes to oxidative stress and inflammation in knee osteoarthritis patients with metabolic syndrome. Clin Exp Rheumatol. Published 5 January 2024. doi:10.
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