Osteoarthritis

Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis

N Engl J MedPublished Randomised controlled trial

Primary result · Oxford Hip Score, mean increase (improvement)Result — go to the resultDifference 11.4 points 95% CI 8.9–14.0

Authors' conclusion

In patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery, total hip replacement resulted in a clinically important, superior reduction in hip pain and improved hip function, as reported by patients, at 6 months as compared with resistance training.

Study context

Population
Patients aged ≥50 years with severe hip OA and an indication for surgerymean age 67.6 years
Participants
109 patients
Comparison
Total hip replacement vs resistance training
  • Total hip replacementn = 53
  • Resistance trainingn = 56reference
Primary endpoint
Change in patient-reported hip pain and function, Oxford Hip Score (0–48, higher scores indicating less pain and better function)
Follow-up
6 months
Methodological detailsmulticentre
  • Multicentre

Primary result

Oxford Hip Score, mean increase (improvement)

Difference

11.4 points

95% CI 8.9–14.0

P < 0.001

Change by group

Total hip replacement

15.9

mean · points

Resistance training

4.5

mean · points

Total hip replacementvs Resistance training
difference 11.4 points (95% CI 8.9–14.0); P < 0.001

As reported in the abstract

Further findings

Crossover/non-adherence to assigned treatment · 6 months

  • Crossover/non-adherence to assigned treatment: Total hip replacement: had not undergone surgery; Resistance training: had undergone total hip replacement

Safety

Serious adverse events · 6 months

Incidence similar in the two groups; majority were known complications of total hip replacement

Original publication

Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis. N Engl J Med. Published 31 October 2024. doi:10.1056/nejmoa2400141

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