How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects
Authors' conclusion
Increased arthritis self-efficacy, reduced fear of movement, and weight loss may partially mediate telehealth-delivered exercise program effects, with and without diet, on pain and/or function in knee OA.
Study context
- Population
- People with knee osteoarthritis (OA)
- Participants
- 345 people
- Comparison
- Exercise program and Diet + Exercise program vs Control program
- Primary endpoint
- Mediators (change at 6 months in attitudes toward self-management, fear of movement, arthritis self-efficacy, weight, physical activity, willingness for knee surgery) of changes in pain (11-point NRS) and function (WOMAC, 0-68)
- Follow-up
- 12 months
Methodological details3-arm, mediation analysis, telehealth-delivered
- 3-arm
- Mediation analysis
- Telehealth-delivered
Primary result
As reported in the abstract
- Exercise vs Control
- Mediated effect via reduced fear of movement, function −1.11 units (95% CI −2.15 to −0.07)
- Exercise vs Control
- Mediated effect via increased self-efficacy, pain −0.40 units (95% CI −0.75 to −0.06)
- Exercise vs Control
- Mediated effect via increased self-efficacy, function −1.66 units (95% CI −3.04 to −0.28)
- Diet + Exercise vs Control
- Mediated effect via reduced fear of movement, function −1.13 units (95% CI −2.17 to −0.08)
- Diet + Exercise vs Control
- Mediated effect via increased self-efficacy, pain −0.77 units (95% CI −1.26 to −0.28)
- Diet + Exercise vs Control
- Mediated effect via increased self-efficacy, function −5.15 units (95% CI −7.34 to −2.96)
- Diet + Exercise vs Control
- Mediated effect via weight loss, pain −1.20 units (95% CI −1.73 to −0.68)
- Diet + Exercise vs Control
- Mediated effect via weight loss, function −5.79 units (95% CI −7.96 to −3.63)
- Diet + Exercise vs Exercise
- Mediated effect via weight loss, pain −0.89 units (95% CI −1.31 to −0.47)
- Diet + Exercise vs Exercise
- Mediated effect via weight loss, function −4.02 units (95% CI −5.77 to −2.26)
Original publication
How Does Exercise, With and Without Diet, Improve Pain and Function in Knee Osteoarthritis? A Secondary Analysis of a Randomized Controlled Trial Exploring Potential Mediators of Effects. Arthritis Care Res (Hoboken). Published 15 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →