Prevalence of Nonsteroidal Antiinflammatory Drugs Prescribed for Osteoarthritis: A Systematic Review and Meta‐Analysis of Observational Studies
Authors' conclusion
Data from over 6.4 million participants with osteoarthritis between 1989 and 2022 indicate that NSAID prescribing has decreased over time and that prescribing differs between geographic locations.
Study context
- Population
- Participants with diagnosed OA of any region prescribed nonsteroidal antiinflammatory drugs (NSAIDs) by their health care provider; studies published 1989–2022, mostly Europe and Central Asia and North America
- Participants
- 6,494,509 participants51 studies
- Outcome
- Proportion of participants with OA prescribed NSAIDs by their health care provider
Methodological detailsrandom and fixed-effects meta-analysis, meta-regression, GRADE quality assessment, Most studies judged at low risk of bias (75%), Mean age of participants 64.7 years (95% CI 62.4, 67.0; n = 34 studies)
- Random and fixed-effects meta-analysis
- Meta-regression
- GRADE quality assessment
- Most studies judged at low risk of bias (75%)
- Mean age of participants 64.7 years (95% CI 62.4, 67.0; n = 34 studies)
Pooled result
As reported in the abstract
Pooled prevalence of NSAID prescribing in OA (high risk of bias studies removed)
Pooled estimate of NSAID prescribing, %
43.8%
95% CI 36.8, 51.1
Further pooled results
Meta-regression: factors associated with prescribing
- Year (decreased prescribing over time), P = 0.05
- Geographic region (higher in Europe and Central Asia and in South Asia than in North America), P = 0.03
- Not associated with clinical setting
Original publication
Prevalence of Nonsteroidal Antiinflammatory Drugs Prescribed for Osteoarthritis: A Systematic Review and Meta‐Analysis of Observational Studies. Arthritis Care Res (Hoboken). Published 19 June 2023. doi:10.
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