Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study
Authors' conclusion
Synovial tissue damage is associated with pain in late-stage knee OA, independent from inflammation and radiographic damage.
Study context
- Population
- Patients undergoing surgery for painful late-stage (Kellgren-Lawrence Grade 3 or 4) knee osteoarthritis (OA)Ultrasound (US) measures in 118
- Participants
- 122 patients
- Exposure
- Histopathological features of synovial inflammation vs synovial tissue damage, related to US synovitis and pain
- Outcome
- Associations of histopathological synovial inflammation and tissue damage with US synovitis and pain (KOOS)
Methodological detailslinear or logistic regression controlling for covariates
- Linear or logistic regression controlling for covariates
Main finding
As reported in the abstract
Histopathological inflammation and moderate/severe US synovitis, OR
1.34
95% CI 1.04, 1.74
Synovial tissue damage and moderate/severe US synovitis, OR
0.77
95% CI 0.57, 1.03
Worse synovial tissue damage scores and pain (KOOS; more pain), estimate
−1.47
95% CI −2.88, −0.05
Synovial tissue damage and pain, adjusted for synovial inflammation, estimate
−1.61
95% CI −3.12, −0.10
Observational data: associations, not effects.
Original publication
Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study. Osteoarthritis Cartilage. Published 4 July 2024. doi:10.
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